| + |
PRKG2 |
phosphorylation
|
LASP1 |
0.348 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249197 |
Ser146 |
MEPERRDsQDGSSYR |
Homo sapiens |
|
| pmid |
sentence |
| 12571245 |
Recombinant human LASP was phosphorylated by cGMP- and cAMP-dependent protein kinase (cAK) in vitro. Cotransfection of PtK-2 cells with LASP and cGK confirmed phosphorylation of LASP in vivo. Studies with human LASP mutants identified serine 146 as a specific phosphorylation site for cGK and cAK in vivo. LASP is an actin-binding protein, and the phospho-LASP-mimicking mutant S146D showed reduced binding affinity for F-actin in cosedimentation experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKCB | down-regulates activity 
phosphorylation
|
LASP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97942 |
Ser146 |
MEPERRDsQDGSSYR |
Homo sapiens |
|
| pmid |
sentence |
| 12571245 |
Actin binding of human lim and sh3 protein is regulated by cgmp- and camp-dependent protein kinase phosphorylation on serine 146. Phosphorylation of lasp at ser-146 leads to a redistribution of the actin-bound protein from the tips of the cell membrane to the cytosol, accompanied with a reduced cell migration |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | down-regulates activity
phosphorylation
|
LASP1 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250074 |
Ser146 |
MEPERRDsQDGSSYR |
in vitro |
|
| pmid |
sentence |
| 12432067 |
Lasp-1 binds to non-muscle filamentous (F) actin in vitro in a phosphorylation-dependent manner. Phosphorylation of recombinant lasp-1 with recombinant PKA increased the Kd and decreased the Bmax for lasp-1 binding to F-actin. PKA-dependent phosphorylation sites in rabbit lasp-1 to S99 and S146 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97938 |
Ser146 |
MEPERRDsQDGSSYR |
Homo sapiens |
|
| pmid |
sentence |
| 12571245 |
Actin binding of human lim and sh3 protein is regulated by cgmp- and camp-dependent protein kinase phosphorylation on serine 146. Phosphorylation of lasp at ser-146 leads to a redistribution of the actin-bound protein from the tips of the cell membrane to the cytosol, accompanied with a reduced cell migration |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197720 |
Ser146 |
MEPERRDsQDGSSYR |
Homo sapiens |
|
| pmid |
sentence |
| 22665060 |
Phosphorylation of lasp-1 by pka at serine 146 induces translocation of the lasp-1/zo-2 complex from the cytoplasm to the nucleus. Interaction occurs within the carboxyterminal proline-rich motif of zo-2 and the sh3 domain in lasp-1. |
|
| Publications: |
3 |
Organism: |
In Vitro, Homo Sapiens |
| + |
PRKG1 | down-regulates activity
phosphorylation
|
LASP1 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97946 |
Ser146 |
MEPERRDsQDGSSYR |
Homo sapiens |
|
| pmid |
sentence |
| 12571245 |
Studies with human lasp mutants identified serine 146 as a specific phosphorylation site for cgk and cak in vivo. Lasp is an actin-binding protein, and the phospho-lasp-mimicking mutant s146d showed reduced binding affinity for f-actin in cosedimentation experiments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates activity 
phosphorylation
|
LASP1 |
0.311 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250075 |
Ser99 |
KNKGKGFsVVADTPE |
in vitro |
|
| pmid |
sentence |
| 12432067 |
Lasp-1 binds to non-muscle filamentous (F) actin in vitro in a phosphorylation-dependent manner. Phosphorylation of recombinant lasp-1 with recombinant PKA increased the Kd and decreased the Bmax for lasp-1 binding to F-actin. PKA-dependent phosphorylation sites in rabbit lasp-1 to S99 and S146 |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
BCR-ABL |
phosphorylation
|
LASP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271703 |
Tyr171 |
IPTSAPVyQQPQQQP |
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 24913448 |
LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia|We demonstrate that LASP1 is specifically phosphorylated by BCR-ABL at tyrosine-171 in CML patients |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SRC | up-regulates activity
phosphorylation
|
LASP1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271706 |
Tyr171 |
IPTSAPVyQQPQQQP |
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 19718473 |
Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
LASP1 |
0.351 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124719 |
Tyr171 |
IPTSAPVyQQPQQQP |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 15138294 |
C-abl activation by apoptotic agents specifically promotes phosphorylation of lasp-1 at tyrosine 171, which is associated with the loss of lasp-1 localization to focal adhesions and induction of cell death. Thus, lasp-1 is a dynamic focal adhesion protein necessary for cell migration and survival in response to growth factors and ecm proteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LASP1
- 
- 