| + |
NEK7 | up-regulates activity 
phosphorylation
|
KIF14 |
0.385 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266420 |
Ser1217 |
PIKNLHSsHSSGLMD |
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28630147 |
Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localization to the central spindle in anaphase cells was completely abolished (Fig. 6 C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266419 |
Ser1219 |
KNLHSSHsSGLMDKS |
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28630147 |
Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localization to the central spindle in anaphase cells was completely abolished (Fig. 6 C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266418 |
Ser1220 |
NLHSSHSsGLMDKSS |
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28630147 |
Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localization to the central spindle in anaphase cells was completely abolished (Fig. 6 C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266416 |
Ser56 |
NDDPLLRsAGKVRDI |
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28630147 |
Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localization to the central spindle in anaphase cells was completely abolished (Fig. 6 C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266417 |
Ser607 |
NLIDLAGsERCSTAH |
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 28630147 |
Nek7 direct phosphorylation is required for the anaphase localization of Kif14. we generated an EGFP-Kif14-5A construct in which Ser56, Ser607, Ser1217, Ser1219, and Ser1220 were all mutated to Ala. When transfected into HeLa cells, EGFP-Kif14-5A was expressed to similar levels as WT Kif14 (Fig. S3 C), but its localization to the central spindle in anaphase cells was completely abolished (Fig. 6 C). |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
PRC1 | up-regulates activity
binding
|
KIF14 |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266423 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431929 |
KIF14 interacts with PRC1 and citron kinase. We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. I |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF14 | up-regulates 
|
Plus-end directed sliding movement |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19773780 |
In general, N-kinesins and C-kinesins drive microtubule plus end- and minus end-directed motilities, respectively, and M-kinesins depolymerize microtubules1,9 (Box 1).|Forty-five genes that encode kinesin superfamily proteins (also known as KIFs) have been discovered in the mouse and human genomes.|KIFs are molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs, along the microtubule system. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF14 | up-regulates
|
Cilium_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266421 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32348467 |
We show that RNAi depletion of KIF14 specifically leads to defects in ciliogenesis and basal body (BB) biogenesis, as its absence hampers the efficiency of primary cilium formation and the dynamics of primary cilium elongation, and disrupts the localization of the distal appendage proteins SCLT1 and FBF1 and components of the IFT-B complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CIT | up-regulates activity
binding
|
KIF14 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266424 |
|
|
Homo sapiens |
HEL Cell |
| pmid |
sentence |
| 16431929 |
We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. In KIF14-depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Furthermore, the localization of KIF14 and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KIF14 | up-regulates activity
binding
|
CIT |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16431929 |
We find that KIF14 targets to the central spindle via its interaction with PRC1 and has an essential function in cytokinesis. In KIF14-depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Furthermore, the localization of KIF14 and citron kinase to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
KIF14
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