+ |
PRKCD | up-regulates activity
phosphorylation
|
NCF4 |
0.361 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249012 |
Thr154 |
LRRLRPRtRKVKSVS |
Homo sapiens |
HL-60 Cell |
pmid |
sentence |
9804763 |
P40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKCA | up-regulates activity
phosphorylation
|
NCF4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277628 |
Thr154 |
LRRLRPRtRKVKSVS |
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
34264265 |
In murine and guinea pig neutrophils, PKCδ is required for the phosphorylation of p40phox, a subunit of the NADPH oxidase complex (Li et al., 2016; Someya et al., 1999). In particular, it mediates phosphorylation of the threonine 154 (T154) residue of p40phox, a key regulatory step in the activation of the NADPH oxidase complex in peripheral neutrophils and B cells, in both mice and humans. In conclusion, the EBV-B cells of patients with PKCδ deficiency have impaired ROS production, associated with lower levels of phosphorylation of the cytosolic NADPH oxidase subunit p40phox by PKCδ. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NCF4 | form complex
binding
|
Phagocyte NADPH oxidase complex |
0.634 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-277629 |
|
|
Homo sapiens |
|
pmid |
sentence |
37263099 |
NADPH oxidase is composed of essential protein components in its active state: membranous subunits, including p22-phox and gp91-phox, and cytoplasmic subunits, including p47-phox, p67-phox, p40-phox, and RAC2 (in neutrophils), among which NCF4 encodes the cytoplasmic subunit p40-phox |
|
Publications: |
1 |
Organism: |
Homo Sapiens |