| + |
PRKCD |
phosphorylation
|
CYTH1 |
0.324 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249098 |
Ser394 |
ARKKKVSsTKRH |
Homo sapiens |
JURKAT E-6.1 Cell |
| pmid |
sentence |
| 11438522 |
We show here that a serine/threonine motif within the short polybasic stretch of cytohesin-1 is phosphorylated by purified protein kinase C delta in vitro. Furthermore, the respective residues are also found to be phosphorylated after phorbol ester stimulation in vivo. Biochemical and functional analyses show that phosphorylated cytohesin-1 is able to tightly associate with the actin cytoskeleton, and we further demonstrate that phosphorylation of the protein is required for maximal leukocyte function antigen-1-mediated adhesion of Jurkat cells to intercellular adhesion molecule 1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249099 |
Thr395 |
RKKKVSStKRH |
Homo sapiens |
JURKAT E-6.1 Cell |
| pmid |
sentence |
| 11438522 |
We show here that a serine/threonine motif within the short polybasic stretch of cytohesin-1 is phosphorylated by purified protein kinase C delta in vitro. Furthermore, the respective residues are also found to be phosphorylated after phorbol ester stimulation in vivo. Biochemical and functional analyses show that phosphorylated cytohesin-1 is able to tightly associate with the actin cytoskeleton, and we further demonstrate that phosphorylation of the protein is required for maximal leukocyte function antigen-1-mediated adhesion of Jurkat cells to intercellular adhesion molecule 1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FYN | up-regulates activity 
phosphorylation
|
CYTH1 |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26224309 |
Fyn directly binds, phosphorylates, and activates cytohesin-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CYTH1
- 
- 