+ |
TESK1 | up-regulates activity
phosphorylation
|
TESK1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260825 |
Ser220 |
EPLAVVGsPYWMAPE |
in vitro |
|
pmid |
sentence |
10207045 |
These results suggest that autophosphorylation of Ser-215 is an important step to positively regulate the kinase activity of TESK1. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246667 |
Ser220 |
EPLAVVGsPYWMAPE |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
10207045 |
Site-directed mutagenesis analyses revealed that Ser-215 within the activation loop of the kinase domain is the site of serine autophosphorylation of TESK1. Replacement of Ser-215 by alanine almost completely abolished serine autophosphorylation and histone H3 kinase activities. |
|
Publications: |
2 |
Organism: |
In Vitro, Homo Sapiens |
+ |
TESK1 | down-regulates activity
phosphorylation
|
CFL1 |
0.545 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246723 |
Ser3 |
sGVAVSDG |
Homo sapiens |
Testis |
pmid |
sentence |
11418599 |
Like TESK1, TESK2 phosphorylated cofilin specifically at Ser-3 and induced formation of actin stress fibers and focal adhesionsExpression of cofilin or S3A-cofilin into HeLa cells induced marked decreases in rhodamine-phalloidin staining due to the actin binding and -depolymerizing activity of cofilin |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-106777 |
Ser3 |
sGVAVSDG |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
11294912 |
These results suggest that TESK1 functions downstream of integrins and plays a key role in integrin-mediated actin reorganization, presumably through phosphorylating and inactivating cofilin. We propose that tesk1 and lim-kinases commonly phosphorylate cofilin but are regulated in different ways and play distinct roles in actin reorganization in living cells. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
TESK1 | down-regulates activity
phosphorylation
|
CFL2 |
0.326 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-246719 |
Ser3 |
sGVTVNDE |
Homo sapiens |
Testis |
pmid |
sentence |
11418599 |
Like TESK1, TESK2 phosphorylated cofilin specifically at Ser-3 and induced formation of actin stress fibers and focal adhesionsExpression of cofilin or S3A-cofilin into HeLa cells induced marked decreases in rhodamine-phalloidin staining due to the actin binding and -depolymerizing activity of cofilin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SPRY4 | down-regulates activity
binding
|
TESK1 |
0.583 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253032 |
|
|
Homo sapiens |
|
pmid |
sentence |
15584898 |
Spry4 negatively regulates the kinase activity of TESK1 by associating with it through the C-terminal cysteine-rich region of Spry4 |
|
Publications: |
1 |
Organism: |
Homo Sapiens |