Summary

Name KCNJ8
Full Name ATP-sensitive inward rectifier potassium channel 8
Synonyms Inward rectifier K(+) channel Kir6.1, Potassium channel, inwardly rectifying subfamily J member 8, uKATP-1 |
Primary ID Q15842
Links - -
Type protein
Relations 3
Inhibitors phenformin
Function This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding KATP channel 0.64
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition KCNJ8 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Smooth Muscle
+ down-regulates activity img/direct_inhibition.png binding NLRP3 0.2
Publications: 1 Organism: Homo Sapiens