Relation Results

Name	PAN2 View Modifications
Full Name	PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Synonyms	EC 3.1.13.4, Inactive ubiquitin carboxyl-terminal hydrolase 52, PAB1P-dependent poly(A, Poly(A, PAN deadenylation complex subunit 2 \| KIAA0710, USP52
Primary ID	Q504Q3
Links	- -
Type	protein
Relations	3
Function	Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. {ECO:0000255\|HAMAP-Rule:MF_03182, ECO:0000269\|PubMed:14583602, ECO:0000269\|PubMed:16284618, ECO:0000269\|PubMed:23398456}.