| + |
DCX DET1-COP1 | down-regulates quantity by destabilization 
ubiquitination
|
CRTC2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271666 |
Lys212 |
LDGEMDPkVPAIEEN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17805301 |
In the presence of relevant cofactors (DDB1, DET1), COP1 promoted the ubiquitination of wild-type but not COP1-interaction defective VP/AA TORC2 (Fig. 3e). COP1 also stimulated the ubiquitination of TORC2(K213R) but had no effect on TORC2(K628R), suggesting an important role for Lys 628 in this regard (Fig. 3e). We performed mass spectrometry studies to characterize residues in TORC2 that undergo COP1-mediated ubiquitination. This analysis revealed one major (Lys 628) and one minor (Lys 213) site on TORC2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271665 |
Lys629 |
DSSPGFSkEIAAALA |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17805301 |
In the presence of relevant cofactors (DDB1, DET1), COP1 promoted the ubiquitination of wild-type but not COP1-interaction defective VP/AA TORC2 (Fig. 3e). COP1 also stimulated the ubiquitination of TORC2(K213R) but had no effect on TORC2(K628R), suggesting an important role for Lys 628 in this regard (Fig. 3e). We performed mass spectrometry studies to characterize residues in TORC2 that undergo COP1-mediated ubiquitination. This analysis revealed one major (Lys 628) and one minor (Lys 213) site on TORC2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates
phosphorylation
|
CRTC2 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216541 |
Ser170 |
PSALNRTsSDSALHT |
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Collectively, these findings suggest ampk suppresses glucose production through two transcriptional effects:reduced expression of creb targets via crtc inactivation and reduced expression of foxo target genes via class iia hdac inactivation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216576 |
Ser171 |
SALNRTSsDSALHTS |
Mus musculus |
Hepatocyte |
| pmid |
sentence |
| 20577053 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
PRKAA1 | down-regulates
phosphorylation
|
CRTC2 |
0.534 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176426 |
Ser170 |
PSALNRTsSDSALHT |
Homo sapiens |
|
| pmid |
sentence |
| 21892142 |
Collectively, these findings suggest ampk suppresses glucose production through two transcriptional effects:reduced expression of creb targets via crtc inactivation and reduced expression of foxo target genes via class iia hdac inactivation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates
phosphorylation
|
CRTC2 |
0.743 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166372 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142218 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK1 | down-regulates
phosphorylation
|
CRTC2 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147707 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16817901 |
These results suggested that sik1 could phosphorylate all torcs and thereby repress their transactivation activities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA2 | down-regulates
phosphorylation
|
CRTC2 |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166365 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142211 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-140238 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16148943 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SIK3 | down-regulates activity
phosphorylation
|
CRTC2 |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249172 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249170 |
Ser348 |
PSLQSSLsNPNLQAS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249171 |
Ser70 |
RSSHYGGsLPNVNQI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SIK1 | down-regulates activity
phosphorylation
|
CRTC2 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249168 |
Ser348 |
PSLQSSLsNPNLQAS |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249169 |
Ser70 |
RSSHYGGsLPNVNQI |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 16306228 |
We found that QSK and SIK phosphorylated TORC2 at Ser171 as well as at least two additional residues, namely Ser70 and Ser348|QIK also phosphorylates the CREB co-activator TORC2, in unstimulated cells, to sequester it in the cell cytoplasm, thereby inhibiting CREB-dependent gene-expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates quantity 
transcriptional regulation
|
G6P |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270253 |
|
|
Pongo pygmaeus |
HeLa Cell |
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267788 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
2 |
Organism: |
Pongo Pygmaeus, Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
metformin | down-regulates 
|
CRTC2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
It has been proposed that metformin stimulates crtc2 phosphorylation in response to metabolic signals such as energy stress through the lkb1-ampk/sik1 pathways, which promotes binding to 14-3-3 proteins, thereby sequestering crtc2 from the nucleus to the cytoplasm |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166361 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
It has been proposed that metformin stimulates crtc2 phosphorylation in response to metabolic signals such as energy stress through the lkb1-ampk/sik1 pathways, which promotes binding to 14-3-3 proteins, thereby sequestering crtc2 from the nucleus to the cytoplasm |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
PCK1 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256106 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
These results reveal that CRTC2 plays an essential role in the regulation of hepatic gluconeogenesis through coordinated regulation of the glucocorticoid/GR- and glucagon/CREB-signaling pathways on the key genes G6P and PEPCK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Glycolysis and Gluconeogenesis |
| + |
CRTC2 | up-regulates activity
binding
|
NR3C1 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256101 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
We show here that CRTC2 also functions as a coactivator for the glucocorticoid receptor (GR). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
TSC22D3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256109 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
CRTC2 knockdown attenuates glucocorticoid-responsive GILZ mRNA expression in HeLa cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates quantity
transcriptional regulation
|
G6PC1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256103 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
Further, CRTC2 is required for the glucocorticoid-associated cooperative mRNA expression of the glucose-6-phosphatase, a rate-limiting enzyme for hepatic gluconeogenesis, by facilitating the attraction of GR and itself to its promoter region already occupied by CREB |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | down-regulates quantity
ubiquitination
|
CRTC2 |
0.305 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278725 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27990298 |
Consistently, TRAF6 reduced G6pase gene expression or reporter activity induced by wild-type CRTC1 and CRTC2 but not TRAF6-interaction-defective CRTC1 and CRTC2 (XREF_FIG and XREF_SUPPLEMENTARY).|Indeed, TRAF6, the E3 ubiquitin ligase activated by IL-1beta associates with and ubiquitinates CRTC2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRTC2 | up-regulates activity
binding
|
CREB1 |
0.908 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26652733 |
The cAMP-response element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) is a coactivator known to be specific to CREB and plays a central role in the glucagon-mediated activation of gluconeogenesis in the early phase of fasting |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CRTC2
- 
- 