3.0
Summary
| Name |  CROCCView Modifications |
| Full Name | Rootletin |
| Synonyms | Ciliary rootlet coiled-coil protein | KIAA0445 |
| Primary ID | Q5TZA2 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CDK2 | down-regulates 
phosphorylation
|
CROCC | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CCDC102B | up-regulates activity 
binding
|
CROCC | 0.2 |
| Publications: | 1 | |||
| + | LRRC45 | up-regulates activity
binding
|
CROCC | 0.452 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CROCC | down-regulates
|
Centrosome_separation | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |