Summary

Name ABRAXAS1
Full Name BRCA1-A complex subunit Abraxas 1
Synonyms Coiled-coil domain-containing protein 98, Protein FAM175A | ABRA1, CCDC98
Primary ID Q6UWZ7
Links - -
Type protein
Relations 4
Function Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation ABRAXAS1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BRCA1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding BRCA1-A complex 0.2
Publications: 1 Organism: Homo Sapiens