| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268167 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25881791 |
In the presence of netrin-1, UNC5 co-immuno-precipitates with DCC, suggesting the formation of a ternary complex of netrin-1 with ecto-domains of DCC and UNC5. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. DCC binding to netrin-1 alone leads to axon attraction. Importantly, DCC has the ability to switch the netrin-1-mediated responses from attraction to repulsion when another receptor UNC5 co-exists. |
|
3.0
UNC5D
- 
- 
binding