Summary

Name RRAGA
Full Name Ras-related GTP-binding protein A
Synonyms Rag A, RagA, Adenovirus E3 14.7 kDa-interacting protein 1, FIP-1
Primary ID Q7L523
Links - -
Type protein
Relations 3
Function Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding RAGAD
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding RAGAC
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png gtpase-activating protein RRAGA
Publications: 1 Organism: In Vitro