3.0
Summary
| Name |  RRM2BView Modifications |
| Full Name | Ribonucleoside-diphosphate reductase subunit M2 B |
| Synonyms | TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2 | P53R2 |
| Primary ID | Q7LG56 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates 
phosphorylation
|
RRM2B | 0.527 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RRM2B | up-regulates activity
binding
|
RRM1 | 0.932 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UV stress | up-regulates 
|
RRM2B | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |