Relation Results

Summary

Name GATAD2A
Full Name Transcriptional repressor p66-alpha
Synonyms Hp66alpha, GATA zinc finger domain-containing protein 2A |
Primary ID Q86YP4
Links - -
Type protein
Relations 2
Function Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.

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Type: Score: Layout: SPV 
0.8310.83GATAD2AMBD2/NuRD complexMBD3/NuRD complex

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Relations
Regulator
Mechanism
target
score ℹ
+ GATAD2Aform complex img/form-complex.png binding MBD2/NuRD complex 0.831
Identifier Residue Sequence Organism Cell Line
SIGNOR-263846 Homo sapiens
pmid sentence
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes. This complex is important for early development and for the stability and repair of our genes. Three proteins make up its core: HDAC1, which removes the acetyl group from the nucleosome; MTA1, which acts as a scaffold to hold the complex together; and RBBP4, which enables the complex to interact with nucleosomes. MBD2 and MBD3 are members of the methyl cytosine-guanosine (CpG)-binding domain (MBD) family of proteins42; 43. Of the five MBD members, only MBD2 and MBD3 associate with NuRD and are required for the complex formation and gene repression.
Publications: 1 Organism: Homo Sapiens
+ GATAD2Aform complex img/form-complex.png binding MBD3/NuRD complex 0.83
Identifier Residue Sequence Organism Cell Line
SIGNOR-263858 Homo sapiens
pmid sentence
The NuRD complex is a multi-protein transcriptional corepressor that couples histone deacetylase and ATP-dependent chromatin remodelling activities.In humans, an assembly of proteins called the NuRD complex makes chromatin more compact by removing acetyl groups from nucleosomes.
Publications: 1 Organism: Homo Sapiens
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