Relation Results

Summary

Name LMTK2
Full Name Serine/threonine-protein kinase LMTK2
Synonyms Apoptosis-associated tyrosine kinase 2, Brain-enriched kinase, hBREK, CDK5/p35-regulated kinase, CPRK, Kinase/phosphatase/inhibitor 2, Lemur tyrosine kinase 2, Serine/threonine-protein kinase KPI-2 | AATYK2, BREK, KIAA1079, KPI2, LMR2
Primary ID Q8IWU2
Links - -
Type protein
Relations 5
Function Phosphorylates PPP1C, phosphorylase b and CFTR.

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Type: Score: Layout: SPV 
0.5060.4080.582CDK5LMTK2CFTRPPP1CA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK5up-regulates img/direct-activation.png phosphorylation LMTK2 0.506
Identifier Residue Sequence Organism Cell Line
SIGNOR-195329 Ser1450 LQTSKYFsPPPPARS Homo sapiens Neuron
pmid sentence
Here, we demonstrate that lmtk2 is phosphorylated on serine-1418 (lmtk2ser ) by cdk5/p35 and present evidence that this regulates its ability to phosphorylate pp1cthr __
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ LMTK2down-regulates activity img/direct_inhibition.png phosphorylation CFTR 0.408
Identifier Residue Sequence Organism Cell Line
SIGNOR-278227 Ser737 EPLERRLsLVPDSEQ Homo sapiens
pmid sentence
The present study discovered that in human airway epithelial cells CFTR endocytosis is regulated by the LMTK2-mediated phosphorylation of CFTR-Ser737 that decreases the cell surface density of CFTR Cl\u2212 channels and inhibits CFTR-mediated Cl\u2212 secretion.|Together, the above results demonstrate that the LMTK2 phosphorylation of CFTR-Ser737 facilitates CFTR endocytosis and reduces the plasma membrane abundance of CFTR in human airway epithelial cells.
Publications: 1 Organism: Homo Sapiens
+ LMTK2down-regulates activity img/direct_inhibition.png phosphorylation PPP1CA 0.582
Identifier Residue Sequence Organism Cell Line
SIGNOR-94631 Thr320 NPGGRPItPPRNSAK Homo sapiens
pmid sentence
Kpi-2 kinase domain phosphorylated protein phosphatase-1 (pp1c) at thr(320), which attenuated pp1c activity.
Publications: 1 Organism: Homo Sapiens
+ CDK5down-regulates img/direct_inhibition.png phosphorylation LMTK2 0.506
Identifier Residue Sequence Organism Cell Line
SIGNOR-102652 Homo sapiens
pmid sentence
Cprk displays catalytic activity in in vitro kinase assays and is itself phosphorylated by cdk5/p35. Cdk5/p35 inhibits cprk activity.
Identifier Residue Sequence Organism Cell Line
SIGNOR-102717 Homo sapiens
pmid sentence
Cprk displays catalytic activity in in vitro kinase assays and is itself phosphorylated by cdk5/p35. Cdk5/p35 inhibits cprk activity.
Publications: 2 Organism: Homo Sapiens
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