| + |
PLK1 | down-regulates activity 
dephosphorylation
|
STAG2 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275534 |
Ser1137 |
KRLRPEDsFMSVYPM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15737063 |
Two phosphorylation sites in Scc1 (Thr144 and Thr312) match the consensus proposed by Nakajima et al. [24]. These two sites, in addition to one in Scc1 (Ser454) and three in SA2 (Thr1109, Ser1137, and Ser1224) conform with the consensus proposed by Barr et al. [25]. These findings are consistent with the possibility that at least some of the sites in Scc1 and SA2 are directly phosphorylated by Plk1.|Phosphorylation of SA2 Is Essential for the Dissociation of Cohesin from Chromosomes during Prophase and Prometaphase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275532 |
Ser1224 |
PASIMDEsVLGVSMF |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15737063 |
Two phosphorylation sites in Scc1 (Thr144 and Thr312) match the consensus proposed by Nakajima et al. [24]. These two sites, in addition to one in Scc1 (Ser454) and three in SA2 (Thr1109, Ser1137, and Ser1224) conform with the consensus proposed by Barr et al. [25]. These findings are consistent with the possibility that at least some of the sites in Scc1 and SA2 are directly phosphorylated by Plk1.|Phosphorylation of SA2 Is Essential for the Dissociation of Cohesin from Chromosomes during Prophase and Prometaphase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275533 |
Thr1109 |
MWLSREQtLHTPVMM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15737063 |
Two phosphorylation sites in Scc1 (Thr144 and Thr312) match the consensus proposed by Nakajima et al. [24]. These two sites, in addition to one in Scc1 (Ser454) and three in SA2 (Thr1109, Ser1137, and Ser1224) conform with the consensus proposed by Barr et al. [25]. These findings are consistent with the possibility that at least some of the sites in Scc1 and SA2 are directly phosphorylated by Plk1.|Phosphorylation of SA2 Is Essential for the Dissociation of Cohesin from Chromosomes during Prophase and Prometaphase |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SSU72 | up-regulates activity 
dephosphorylation
|
STAG2 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275531 |
Ser1224 |
PASIMDEsVLGVSMF |
|
|
| pmid |
sentence |
| 20818333 |
Additional experiments revealed that Ssu72 directly interacts with Rad21 and SA2 in vitro and in vivo, and associates with sister chromatids in human cells. Interestingly, depletion or mutational inactivation of Ssu72 phosphatase activity caused the premature resolution of sister chromatid arm cohesion, whereas the overexpression of Ssu72 yielded high resistance to this resolution.|anti‐phospho SA2 serine 1224 |
|
| Publications: |
1 |
| + |
STAG2 | up-regulates quantity by stabilization
binding
|
RAD21 |
0.964 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28430577 |
Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAG2 | up-regulates 
|
TNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119988 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14660624 |
Stag2 is able to enhance the activity of the tumor necrosis factor alpha, the cd69, and the human immunodeficiency virus long terminal repeat promoters in a nf-kappab-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAG2 | up-regulates
|
CD69 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119985 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14660624 |
Stag2 is able to enhance the activity of the tumor necrosis factor alpha, the cd69, and the human immunodeficiency virus long terminal repeat promoters in a nf-kappab-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
STAG2
- 
- 