3.0
Summary
| Name |  PDZD8
|
| Full Name | PDZ domain-containing protein 8 |
| Synonyms | Sarcoma antigen NY-SAR-84/NY-SAR-104 | PDZK8 |
| Primary ID | Q8NEN9 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). |
binding