Summary

Name KMT2C
Full Name Histone-lysine N-methyltransferase 2C
Synonyms Lysine N-methyltransferase 2C, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3 | HALR, KIAA1506, MLL3
Primary ID Q8NEZ4
Links - -
Type protein
Relations 3
Function Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination KMT2C 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding MLL3 complex 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CD274 0.2
Publications: 1 Organism: Homo Sapiens