4.0
Summary
| Name |  TRIM58View Modifications |
| Full Name | E3 ubiquitin-protein ligase TRIM58 |
| Synonyms | Protein BIA2, RING-type E3 ubiquitin transferase TRIM58, Tripartite motif-containing protein 58 | |
| Primary ID | Q8NG06 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | TRIM58 | up-regulates activity 
ubiquitination
|
DDX58 | 0.2 |
| Publications: | 1 | |||
| + | Ub:E2 | up-regulates activity
ubiquitination
|
TRIM58 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRIM58 | down-regulates quantity by destabilization 
polyubiquitination
|
DYNC1I2 | 0.299 |
| Publications: | 1 | Organism: | In Vitro | |