| + |
ATM | down-regulates activity 
phosphorylation
|
ZNF420 |
0.435 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273513 |
Ser68 |
NTYETELsQWEMSDR |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 19377469 |
These results indicate that Apak is a genuine substrate of ATM kinase. Apak phosphorylation on Ser 68 is critical for p53-mediated apoptosis. in response to DNA damage, ATM is rapidly activated by autophosphorylation and mediates p53 activation through disruption of the Apak–p53 complex by phosphorylating Apak on Ser 68. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZNF420 | down-regulates activity
binding
|
TP53BP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273512 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 19377469 |
These results indicate that Apak is a genuine substrate of ATM kinase. Apak phosphorylation on Ser 68 is critical for p53-mediated apoptosis. in response to DNA damage, ATM is rapidly activated by autophosphorylation and mediates p53 activation through disruption of the Apak–p53 complex by phosphorylating Apak on Ser 68. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ZNF420
- 
- 