| + |
PCDH15 | up-regulates activity 
binding
|
TMC1 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262582 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25114259 |
Although several studies show that the tip links, composed of PCDH15 and CDH23, are required for normal mechanotransduction, it is unclear how they are coupled to the transduction machinery. Likewise, it has been demonstrated that the transmembrane channel-like proteins TMC1 and TMC2 are required for mechanosensitive responses in hair cells, but how they interact with other components of the mechanotransduction complex is not known. Here, we show that TMC1 and TMC2 can interact with PCDH15, thereby establishing a critical connection between the tip link and these putative components of the mechanotransduction channel in hair cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Inner Ear |
| + |
TMC1 | form complex 
binding
|
Hair cells mechanotransduction channel |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262569 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The pore forming subunits of the hair cells mechanotransduction channel still need to be identified, but some candidates have emerged including TMC-1,TMC-2 (Kawashima et al., 2011), Piezo1 and Piezo2 (Coste et al., 2010; Coste et al., 2012). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
CIB2 | up-regulates activity
binding
|
TMC1 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269664 |
|
|
Mus musculus |
Hair Cell |
| pmid |
sentence |
| 28663585 |
Furthermore, we report that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations. We conclude that calcium and integrin-binding protein 2 is required for normal operation of the mechanotransducer channels and is involved in limiting the growth of transducing stereocilia. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
TMC1
- 
- 