Summary

Name CNOT9
Full Name CCR4-NOT transcription complex subunit 9
Synonyms Cell differentiation protein RQCD1 homolog, Rcd-1 | RCD1, RQCD1
Primary ID Q92600
Links - -
Type protein
Relations 3
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding GIGYF1 0.2
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CCR4-NOT complex 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GIGYF2 0.2
Publications: 1 Organism: Homo Sapiens