| + |
UBE2G2 | down-regulates quantity by destabilization 
ubiquitination
|
DIO2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267483 |
Lys237 |
VCIVQRQkIAYLGGK |
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267484 |
Lys244 |
KIAYLGGkGPFSYNL |
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
UBE2J1 | down-regulates quantity by destabilization
ubiquitination
|
DIO2 |
0.387 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267481 |
Lys237 |
VCIVQRQkIAYLGGK |
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267482 |
Lys244 |
KIAYLGGkGPFSYNL |
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
ER residency places D2 physically close to an array of proteins that interact and modify the D2 molecule via ubiquitination and targeting to the proteasomal system, explaining its relatively short half-life. Both ubiquitin conjugases UBC6 and or UBC7 interact with D2 and support D2 ubiquitination. Two Lys residues in D2 are involved in this process, K237 and K244. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO2 | up-regulates quantity 
chemical modification
|
iodide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266953 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34674502 |
Three different deiodinases have been described: iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3. Deiodination is the first step in the activation/inactivation process of THs and involves the removal of removes one iodine atom from the outer tyrosyl ring of T4 to produce T3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO2 | down-regulates quantity
chemical modification
|
L-thyroxine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266949 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8755651 |
Type II iodothyronine deiodinase (DII), which catalyzes deiodination of thyroxine (T4) exclusively on the outer ring (5’-position) to yield T4 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
FOXO3 | up-regulates quantity by expression 
transcriptional regulation
|
DIO2 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256204 |
|
|
|
|
| pmid |
sentence |
| 20978344 |
Forkhead box O3 (FoxO3) was identified as a key molecule inducing D2 expression and thereby increasing intracellular T3 production. Accordingly, FoxO3-depleted primary myoblasts also had a differentiation deficit that could be rescued by high levels of T3. |
|
| Publications: |
1 |
| + |
3',5'-cyclic AMP | up-regulates quantity by expression
|
DIO2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267281 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29892818 |
Dio2 is a cAMP responsive gene. Thus, any signaling pathway or molecule that increases cAMP concentration will stimulate D2 activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
DIO2 | up-regulates quantity by expression
transcriptional regulation
|
MYOD1 |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20978344 |
The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone thyroxine (T4). Here we show that type 2 deiodinase (D2) is essential for normal mouse myogenesis and muscle regeneration. Indeed, D2-mediated increases in T3 were essential for the enhanced transcription of myogenic differentiation 1 (MyoD) and for execution of the myogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DIO2
- 
- 