| + |
SRC | up-regulates activity 
phosphorylation
|
WBP2 |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273567 |
Tyr192 |
MMDGAMGyVQPPPPP |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273568 |
Tyr231 |
AEAAASAyYNPGNPH |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
WBP2 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273581 |
Tyr192 |
MMDGAMGyVQPPPPP |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273582 |
Tyr231 |
AEAAASAyYNPGNPH |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 21642474 |
Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking nuclear entry of WBP2 and its interaction with ERα. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP/TAZ | up-regulates activity
binding
|
WBP2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277670 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25287865 |
The WW domains are essential for YAP-induced cell proliferation (261) and mediate binding of YAP/TAZ to PPxY motif-containing transcription factors such as RUNX, p73, and the cytoplasmic domain of ERBB4 or with the transcriptional cofactor WBP2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
WBP2
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