3.0
Summary
| Name |  ORAI1View Modifications |
| Full Name | Calcium release-activated calcium channel protein 1 |
| Synonyms | Protein orai-1, Transmembrane protein 142A | CRACM1, TMEM142A |
| Primary ID | Q96D31 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928, PubMed:20354224, PubMed:26956484). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). |
phosphorylation