Summary

Name RAB39B
Full Name Ras-related protein Rab-39B
Synonyms RB39B_HUMAN |
Primary ID Q96DA2
Links - -
Type protein
Relations 1
Function Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding PICK1 0.39
Publications: 1 Organism: Chlorocebus Aethiops