| + |
MCRS1 | form complex 
binding
|
INO80 complex |
0.5 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270844 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25016522 |
Here, we have systematically investigated the involvement of the catalytic subunit of the human INO80 complex during unchallenged replication and under replication stress by following the effects of its depletion on cell survival, S-phase checkpoint activation, the fate of individual replication forks, and the consequences of fork collapse. We report that INO80 was specifically needed for efficient replication elongation, while it was not required for initiation of replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MCRS1 | form complex
binding
|
NSL histone acetyltransferase |
0.632 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267161 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20018852 |
Here we report an analysis of the subunit composition and substrate specificity of the NSL complex. Proteomic analyses of complexes purified through multiple candidate subunits reveal that NSL is composed of nine subunits. Two of its subunits, WD repeat domain 5 (WDR5) and host cell factor 1 (HCF1), are shared with members of the MLL/SET family of histone H3 lysine 4 (H3K4) methyltransferase complexes, and a third subunit, MCRS1, is shared with the human INO80 chromatin-remodeling complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MCRS1
- 
- 