3.0
Summary
| Name |  SPATA13
|
| Full Name | Spermatogenesis-associated protein 13 |
| Synonyms | APC-stimulated guanine nucleotide exchange factor 2, Asef2 | |
| Primary ID | Q96N96 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
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