| + |
PCDH15 | up-regulates activity 
binding
|
TMC1 |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262582 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25114259 |
Although several studies show that the tip links, composed of PCDH15 and CDH23, are required for normal mechanotransduction, it is unclear how they are coupled to the transduction machinery. Likewise, it has been demonstrated that the transmembrane channel-like proteins TMC1 and TMC2 are required for mechanosensitive responses in hair cells, but how they interact with other components of the mechanotransduction complex is not known. Here, we show that TMC1 and TMC2 can interact with PCDH15, thereby establishing a critical connection between the tip link and these putative components of the mechanotransduction channel in hair cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Inner Ear |
| + |
PCDH15 | form complex 
binding
|
TIP-LINK complex |
0.566 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262575 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217710 |
The adaptor proteins harmonin and SANS, and the motor protein myosin 7a (Myo7a) bind in vitro to each other and to CDH23 (Adato et al., 2005; Bahloul et al., 2010; Boeda et al., 2002; Siemens et al., 2002) and co-localize at the upper insertion site of tip links (Grati and Kachar, 2011; Grillet et al., 2009b), suggesting that they form a protein complex important for transduction. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
PCDH15 | up-regulates activity
binding
|
TMC2 |
0.448 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262583 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 25114259 |
Although several studies show that the tip links, composed of PCDH15 and CDH23, are required for normal mechanotransduction, it is unclear how they are coupled to the transduction machinery. Likewise, it has been demonstrated that the transmembrane channel-like proteins TMC1 and TMC2 are required for mechanosensitive responses in hair cells, but how they interact with other components of the mechanotransduction complex is not known. Here, we show that TMC1 and TMC2 can interact with PCDH15, thereby establishing a critical connection between the tip link and these putative components of the mechanotransduction channel in hair cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Inner Ear |
3.0
PCDH15
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