Summary

Name SPAG5
Full Name Sperm-associated antigen 5
Synonyms Astrin, Deepest, Mitotic spindle-associated protein p126, MAP126
Primary ID Q96R06
Links - -
Type protein
Relations 7
Function Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation SPAG5 0.275
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CENPF 0.342
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png CENPE 0.383
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png relocalization CDK5RAP2 0.474
Publications: 1 Organism: Homo Sapiens