| + |
PKA | down-regulates 
phosphorylation
|
CAMKK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198146 |
Ser100 |
HLSGRKLsLQERSQG |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Pka phosphorylates ser-100, ser-495, and ser-511the camp/pka pathway can inhibit camkk2 activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198150 |
Ser495 |
KTMIRKRsFGNPFEG |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Pka phosphorylates ser-100, ser-495, and ser-511the camp/pka pathway can inhibit camkk2 activity |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198154 |
Ser511 |
RREERSLsAPGNLLT |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Pka phosphorylates ser-100, ser-495, and ser-511the camp/pka pathway can inhibit camkk2 activity |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
PKA | down-regulates activity
phosphorylation
|
CAMKK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277239 |
Ser100 |
HLSGRKLsLQERSQG |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 32913128 |
Here we show that stimulation of cAMP-dependent protein kinase A (PKA) signaling in cells inactivates CaMKK2 by phosphorylation of three conserved serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277238 |
Ser495 |
KTMIRKRsFGNPFEG |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 32913128 |
Here we show that stimulation of cAMP-dependent protein kinase A (PKA) signaling in cells inactivates CaMKK2 by phosphorylation of three conserved serine residues. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277240 |
Ser511 |
RREERSLsAPGNLLT |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 32913128 |
Here we show that stimulation of cAMP-dependent protein kinase A (PKA) signaling in cells inactivates CaMKK2 by phosphorylation of three conserved serine residues. |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Thyroid Hormone Metabolism |
| + |
GSK3A | down-regulates
phosphorylation
|
CAMKK2 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198122 |
Ser129 |
ICPSLPYsPVSSPQS |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198126 |
Ser133 |
LPYSPVSsPQSSPRL |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198130 |
Ser137 |
PVSSPQSsPRLPRRP |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK5 | down-regulates
phosphorylation
|
CAMKK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198111 |
Ser129 |
ICPSLPYsPVSSPQS |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198115 |
Ser133 |
LPYSPVSsPQSSPRL |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197945 |
Ser137 |
PVSSPQSsPRLPRRP |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates
phosphorylation
|
CAMKK2 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198134 |
Ser129 |
ICPSLPYsPVSSPQS |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198138 |
Ser133 |
LPYSPVSsPQSSPRL |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198142 |
Ser137 |
PVSSPQSsPRLPRRP |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
Cdk5 and gsk3 phosphorylate ser-129, ser-133, and ser-137. Mutation of ser-129, ser-133, and ser-137 increases autonomous activity with little change in ca2 /cam-dependent activity. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
DAPK1 | down-regulates
phosphorylation
|
CAMKK2 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126241 |
Ser511 |
RREERSLsAPGNLLT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15209507 |
Dapk phosphorylates camkk. S511 was identified as the phosphorylation site . a potential mechanism of action was identified on the basis of the location of s511 near the cam recognition domain of camkk and demonstrated by attenuation of cam-stimulated camkk autophosphorylation after dapk phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
DAPK1 |
phosphorylation
|
CAMKK2 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126245 |
Ser511 |
RREERSLsAPGNLLT |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15209507 |
Dapk phosphorylates camkks511 was identified as the phosphorylation site |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
CAMKK2 | up-regulates 
phosphorylation
|
PRKAA2 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138364 |
Thr172 |
SDGEFLRtSCGSPNY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15980064 |
These data indicate that the camkks function in intact cells as ampkks, predicting wider roles for these kinases in regulating ampk activity in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-161929 |
Thr172 |
SDGEFLRtSCGSPNY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19958286 |
These data indicate that the camkks function in intact cells as ampkks, predicting wider roles for these kinases in regulating ampk activity in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CAMKK2 | up-regulates activity
phosphorylation
|
CAMK1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250716 |
Thr177 |
DPGSVLStACGTPGY |
|
|
| pmid |
sentence |
| 7641687 |
Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. |
|
| Publications: |
1 |
| + |
CAMKK2 | up-regulates
phosphorylation
|
PRKAA1 |
0.59 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176602 |
Thr183 |
SDGEFLRtSCGSPNY |
Homo sapiens |
|
| pmid |
sentence |
| 21918180 |
Ampka1 activators increased phosphorylation level and cytoplasmic localization (reduced nuclear/cytoplasmic ratio). Ampka1 activators reduced rna synthesis in the nucleoli. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CAMKK2 | up-regulates activity
phosphorylation
|
CAMK4 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250718 |
Thr200 |
EHQVLMKtVCGTPGY |
|
|
| pmid |
sentence |
| 7615569 |
Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation. |
|
| Publications: |
1 |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CAMKK2 | up-regulates
phosphorylation
|
CAMKK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198107 |
Thr483 |
KHIPSLAtVILVKTM |
Homo sapiens |
|
| pmid |
sentence |
| 22778263 |
It has been proposed that a major consequence of relief from autoinhibition is autophosphorylation of thr-482, a post-translational change that likely contributes to the increased autonomous activity of camkk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CAMKK2 | up-regulates
phosphorylation
|
AMPK |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217496 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15980064 |
These data indicate that the camkks function in intact cells as ampkks, predicting wider roles for these kinases in regulating ampk activity in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALM1 | up-regulates
binding
|
CAMKK2 |
0.827 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-61922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9822657 |
The ca2+-calmodulin-dependent protein kinase (cam kinase) cascade includes three kinases: cam-kinase kinase (camkk);and the cam kinases camki and camkiv, which are phosphorylated and activated by camkk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
CALM2 | up-regulates
binding
|
CAMKK2 |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266329 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9822657 |
The ca2+-calmodulin-dependent protein kinase (cam kinase) cascade includes three kinases: cam-kinase kinase (camkk);and the cam kinases camki and camkiv, which are phosphorylated and activated by camkk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
CALM3 | up-regulates
binding
|
CAMKK2 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266345 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9822657 |
The ca2+-calmodulin-dependent protein kinase (cam kinase) cascade includes three kinases: cam-kinase kinase (camkk);and the cam kinases camki and camkiv, which are phosphorylated and activated by camkk. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CAMKK2
- 
- 