| + |
ATM | up-regulates 
phosphorylation
|
DCLRE1C |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148315 |
Ser503 |
NDEITDEsLENFPSS |
Homo sapiens |
|
| pmid |
sentence |
| 16874298 |
The artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a subset of ionising radiation induced dna double-strand breaks (dsbs) in an atm and dna-pk dependent process. Here, we show that artemis phosphorylation by atm and dna-pk in vitro is primarily attributable to s503, s516 and s645 and demonstrate atm dependent phosphorylation at serine 645 in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148319 |
Ser516 |
SSTVAGGsQSPKLFS |
Homo sapiens |
|
| pmid |
sentence |
| 16874298 |
The artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a subset of ionising radiation induced dna double-strand breaks (dsbs) in an atm and dna-pk dependent process. Here, we show that artemis phosphorylation by atm and dna-pk in vitro is primarily attributable to s503, s516 and s645 and demonstrate atm dependent phosphorylation at serine 645 in vivo |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148323 |
Ser645 |
NLSTNADsQSSSDFE |
Homo sapiens |
|
| pmid |
sentence |
| 16874298 |
The artemis nuclease is defective in radiosensitive severe combined immunodeficiency patients and is required for the repair of a subset of ionising radiation induced dna double-strand breaks (dsbs) in an atm and dna-pk dependent process. Here, we show that artemis phosphorylation by atm and dna-pk in vitro is primarily attributable to s503, s516 and s645 and demonstrate atm dependent phosphorylation at serine 645 in vivo |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
PRKDC | up-regulates
phosphorylation
|
DCLRE1C |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148327 |
Ser503 |
NDEITDEsLENFPSS |
Homo sapiens |
|
| pmid |
sentence |
| 16874298 |
Artemis is a nuclear phosphoprotein required for genomic integrity whose phosphorylation is increased subsequent to dna damage. Artemis phosphorylation by the dna-dependent protein kinase (dna-pk). However, regardless of its association with dna-pkcs, phosphorylation of artemis at both s516 and s645 was stimulated in response to the double-stranded dna-damaging agent bleomycin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145837 |
Ser516 |
SSTVAGGsQSPKLFS |
Homo sapiens |
|
| pmid |
sentence |
| 16600297 |
Artemis is a nuclear phosphoprotein required for genomic integrity whose phosphorylation is increased subsequent to dna damage. Artemis phosphorylation by the dna-dependent protein kinase (dna-pk). However, regardless of its association with dna-pkcs, phosphorylation of artemis at both s516 and s645 was stimulated in response to the double-stranded dna-damaging agent bleomycin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-145841 |
Ser645 |
NLSTNADsQSSSDFE |
Homo sapiens |
|
| pmid |
sentence |
| 16600297 |
Artemis is a nuclear phosphoprotein required for genomic integrity whose phosphorylation is increased subsequent to dna damage. Artemis phosphorylation by the dna-dependent protein kinase (dna-pk). However, regardless of its association with dna-pkcs, phosphorylation of artemis at both s516 and s645 was stimulated in response to the double-stranded dna-damaging agent bleomycin |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
3.0
DCLRE1C
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