Relation Results

Summary

Name PIK3R4
Full Name Phosphoinositide 3-kinase regulatory subunit 4
Synonyms PI3-kinase regulatory subunit 4, PI3-kinase p150 subunit, Phosphoinositide 3-kinase adaptor protein | VPS15
Primary ID Q99570
Links - -
Type protein
Relations 6
Function Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a rol ...
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Type: Score: Layout: SPV 
0.4250.920.940.8850.65RAB5APIK3R4Vps34 Complex IPIK3C3Vps34 Complex IINRBF2

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Relations
Regulator
Mechanism
target
score ℹ
+ RAB5Aup-regulates activity img/direct-activation.png binding PIK3R4 0.425
Identifier Residue Sequence Organism Cell Line
SIGNOR-260708 Mus musculus
pmid sentence
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity
Publications: 1 Organism: Mus Musculus
+ PIK3R4form complex img/form-complex.png binding Vps34 Complex I 0.92
Identifier Residue Sequence Organism Cell Line
SIGNOR-260317 in vitro
pmid sentence
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively.
Publications: 1 Organism: In Vitro
+ PIK3R4up-regulates img/direct-activation.png binding PIK3C3 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-45664 Homo sapiens
pmid sentence
Recombinant p150 associated with ptdins 3-kinase in vitro in a stable manner, resulting in a 2-fold increase in lipid kinase activity.
Publications: 1 Organism: Homo Sapiens
+ PIK3R4form complex img/form-complex.png binding Vps34 Complex II 0.885
Identifier Residue Sequence Organism Cell Line
SIGNOR-260321 in vitro
pmid sentence
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively.
Publications: 1 Organism: In Vitro
+ PIK3R4up-regulates activity img/direct-activation.png binding PIK3C3 0.94
Identifier Residue Sequence Organism Cell Line
SIGNOR-260709 Mus musculus
pmid sentence
Vps34 PI 3-kinase activity18 is stimulated by complex formation with the protein kinase Vps15|Rab5GTP binds Vps15, enhancing Vps34 activity
Publications: 1 Organism: Mus Musculus
+ NRBF2down-regulates activity img/direct_inhibition.png binding PIK3R4 0.65
Identifier Residue Sequence Organism Cell Line
SIGNOR-265878 Homo sapiens U2-OS Cell
pmid sentence
NRBF2 S113 and S120 phosphorylation negatively regulates autophagy. Phosphorylated NRBF2 inhibits autophagy, preferentially binds a nonautophagic form of the PtdIns3K complex consisting of PIK3C3-PIK3R4 only, and this NRBF2-associated PtdIns3K complex has low lipid kinase activity.
Publications: 1 Organism: Homo Sapiens
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