| + |
Ub:E2 | up-regulates activity 
ubiquitination
|
BARD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271102 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK2 | down-regulates activity 
phosphorylation
|
BARD1 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280211 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15665273 |
CDK2-cyclin A1/E1 and CDK1-cyclin B1 phosphorylate BARD1 on its NH(2) terminus in vivo and in vitro. 44999999="E1" 45999998="terminus"}|Here we show that the ubiquitin ligase activity of BRCA1-BARD1 is down-regulated by CDK2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BARD1 | up-regulates
binding
|
BRCA1 |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20029420 |
Brac1 dimerizes with brca1?associated Ring domain protein 1 (bard1) to yield a functional e3 ligase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BARD1 | form complex 
binding
|
BRCA1-BARD1 complex |
0.794 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263223 |
|
|
|
|
| pmid |
sentence |
| 25400280 |
Intriguingly, another BRCA1 complex, the BRCA1–A complex, which itself contains RAP80 along with MERIT40, BRCC36/45 and Abraxas, has been reported to inhibit DNA end resection, suggesting that, in some contexts, BRCA1 may function to limit and/or prevent over resection of DNA breaks. |
|
| Publications: |
1 |
| + |
BARD1 | down-regulates quantity
ubiquitination
|
ESR1 |
0.426 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25740706 |
As shown in xref , both FOXK2 and BARD1 enhanced the ubiquitination of ER\u03b1, with the extent of ubiquitination being enhanced when both FOXK2 and BARD1 were overexpressed.|These findings suggested that FOXK2 might act as a negative regulator of Estrogen receptor\u03b1, and its association with both Estrogen receptor\u03b1 and BRCA1/BARD1 could lead to the down-regulation of Estrogen receptor\u03b1 transcriptional activity, effectively regulating the function of Estrogen receptor\u03b1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
BARD1
- 
- 