3.0
Summary
| Name |  PCGF6View Modifications |
| Full Name | Polycomb group RING finger protein 6 |
| Synonyms | Mel18 and Bmi1-like RING finger, RING finger protein 134 | MBLR, RNF134 |
| Primary ID | Q9BYE7 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Transcriptional repressor (PubMed:12167161). May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
phosphorylation
ubiquitination