Relation Results

Name	TRIM7
Full Name	E3 ubiquitin-protein ligase TRIM7
Synonyms	Glycogenin-interacting protein, RING finger protein 90, Tripartite motif-containing protein 7 \| GNIP, RNF90
Primary ID	Q9C029
Links	- -
Type	protein
Relations	3
Function	E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of pro-inflammatory cytokines and type I interferon (By similarity). Also plays a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).