Summary

Name FKRP
Full Name Fukutin-related protein
Synonyms FKRP_HUMAN |
Primary ID Q9H9S5
Links - -
Type protein
Relations 1
Function Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:25279699, PubMed:26923585, PubMed:29477842). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (PubMed:25279699, PubMed:26923585, PubMed:29477842).

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Relations

Regulator Mechanism target score ℹ
+ FKRPform complex img/form-complex.png binding Fukutin-FKRP-TMEM5 multienzyme complex 0.659
Publications: 1 Organism: Homo Sapiens