+ |
SPC25 | up-regulates activity
binding
|
RIOK1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278893 |
|
|
Homo sapiens |
SKOV-3 Cell |
pmid |
sentence |
39488790 |
This study demonstrates that SPC25 acts as a molecular scaffold, mediating SPC25/RIOK1/MYH9 complex formation and triggering the RIOK1‐mediated phosphorylation of MYH9 at Ser1943.Taken together, these results suggested that SPC25 increases MYH9 phosphorylation at Ser1943, enhancing the nuclear accumulation of MYH9 and consequently modulating the transcription of CTNNB1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SPC25 | up-regulates activity
binding
|
MYH9 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278894 |
|
|
Homo sapiens |
Novikoff Ascites Tumor Cell |
pmid |
sentence |
39488790 |
This study demonstrates that SPC25 acts as a molecular scaffold, mediating SPC25/RIOK1/MYH9 complex formation and triggering the RIOK1‐mediated phosphorylation of MYH9 at Ser1943.Taken together, these results suggested that SPC25 increases MYH9 phosphorylation at Ser1943, enhancing the nuclear accumulation of MYH9 and consequently modulating the transcription of CTNNB1. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SPC25 | form complex
binding
|
Ndc80 complex |
0.974 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265186 |
|
|
|
|
pmid |
sentence |
27881301 |
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits |
|
Publications: |
1 |