Summary

Name BIRC6
Full Name Baculoviral IAP repeat-containing protein 6
Synonyms BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE, Ubiquitin-conjugating BIR domain enzyme apollon, APOLLON | KIAA1289
Primary ID Q9NR09
Links - -
Type protein
Relations 3
Function Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.

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Relations

Regulator Mechanism target score ℹ
+ BIRC6down-regulates img/direct_inhibition.png binding CASP3 0.477
Publications: 1 Organism: Homo Sapiens
+ Ub:E1 (UBA6 substrate)up-regulates activity img/direct-activation.png ubiquitination BIRC6 0.418
Publications: 1 Organism: Homo Sapiens
+ Ub:E1 (UBA1 substrate)up-regulates activity img/direct-activation.png ubiquitination BIRC6 0.388
Publications: 1 Organism: Homo Sapiens