Summary

Name TLR8
Full Name Toll-like receptor 8
Synonyms TLR8_HUMAN
Primary ID Q9NR97
Links - -
Type protein
Relations 4
Function Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce proinflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/indirect-activation.png TNF 0.467
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation TLR8 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TLR8 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation TLR8 0.8
Publications: 1 Organism: Homo Sapiens