| + |
PRKACA | up-regulates 
phosphorylation
|
DUOX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183445 |
Ser1217 |
SHHFRRRsFRGFWLT |
Homo sapiens |
|
| pmid |
sentence |
| 19144650 |
We analyzed the duox1 phosphorylation state with an anti-rxx(ps/pt) antibody that could potentially recognize phosphorylation on ser955 and ser1217 but not on thr1007. duox1 but not duox2 activity is stimulated by forskolin (ec50 = 0.1 _m) via protein kinase a-mediated duox1 phosphorylation on serine 955. duox1 is positively regulated by the camp-dependent protein kinase a (pka)6 cascade |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183449 |
Ser955 |
KDLCRRAsYISQDMI |
Homo sapiens |
|
| pmid |
sentence |
| 19144650 |
We analyzed the duox1 phosphorylation state with an anti-rxx(ps/pt) antibody that could potentially recognize phosphorylation on ser955 and ser1217 but not on thr1007. duox1 but not duox2 activity is stimulated by forskolin (ec50 = 0.1 _m) via protein kinase a-mediated duox1 phosphorylation on serine 955. duox1 is positively regulated by the camp-dependent protein kinase a (pka)6 cascade |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
DUOX1 | up-regulates quantity
chemical modification
|
superoxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264726 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUOX1 | up-regulates
|
ROS |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17237347 |
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
DUOX1
- 
- 