Summary

Name MRGBP
Full Name MRG/MORF4L-binding protein
Synonyms MRG-binding protein, Up-regulated in colon cancer 4, Urcc4 | C20orf20
Primary ID Q9NV56
Links - -
Type protein
Relations 1
Function Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

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Relations

Regulator Mechanism target score ℹ
+ MRGBPform complex img/form-complex.png binding NuA4 complex 0.775
Publications: 1 Organism: Homo Sapiens