| + |
C5AR2 | down-regulates quantity by repression 
|
SELL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263467 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
Avacopan | down-regulates activity 
binding
|
C5AR2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31734405 |
CCX168 (avocapan), a C5aR antagonist, has proven its safety and efficiency in phase I and phase II trials conducted in AAV patients. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C5AR2 | up-regulates quantity by expression 
|
superoxide |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263470 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
C5AR2 | up-regulates quantity by expression
|
CR1 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263465 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
C5AR2 | up-regulates quantity by expression
|
ITGAM |
0.302 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263463 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
C5AR2 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263461 |
|
|
|
|
| pmid |
sentence |
| 1847994 |
The C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a. In addition to stimulating chemotaxis, granule enzyme release and superoxide anion production, this receptor stimulates upregulation of expression and activity of the adhesion molecule MAC-1, and of CR1, and a decrease in cell-surface glycoprotein 100MEL-14 on neutrophils. |
|
| Publications: |
1 |
| + |
C5AR2 | up-regulates
|
Chemotaxis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263459 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9108406 |
We report here that the anaphylatoxins C3a and C5a are chemotactic factors for the human mast cell line HMC-1, human cord blood-derived mast cells (CBMC) and cutaneous mast cells in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
C5 | up-regulates 
binding
|
C5AR2 |
0.647 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-113558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11773063 |
Here we report that the orphan receptor c5l2/gpr77, which shares 35% amino acid identity with cd88, binds c5a with high affinity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
C5AR2
- 
- 