4.0
Summary
| Name |  PSMC3IP
|
| Full Name | Homologous-pairing protein 2 homolog |
| Synonyms | Nuclear receptor coactivator GT198, PSMC3-interacting protein, Proteasome 26S ATPase subunit 3-interacting protein, Tat-binding protein 1-interacting protein, TBP-1-interacting protein | HOP2, TBPIP |
| Primary ID | Q9P2W1 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PSMC3IP | form complex 
binding
|
HOP2-MND1 recombination assembly factor complex | 0.938 |
| Publications: | 1 | Organism: | Homo Sapiens | |