| + |
STK39 | down-regulates activity 
phosphorylation
|
SLC12A6 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276597 |
Ser96 |
IEDLSQNsITGEHSQ |
in vitro |
|
| pmid |
sentence |
| 24043619 |
We observed that in vitro activated STE20/SPS1-related proline/alanine-rich kinase (SPAK) complexed to its regulatory MO25 subunit phosphorylated KCC3 at Ser-96 and that in Xenopus laevis oocytes Ser-96 of human KCC3 is phosphorylated in isotonic conditions and becomes dephosphorylated during incubation in hypotonicity, leading to a dramatic increase in KCC3 function. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
WNK3 | down-regulates activity
phosphorylation
|
SLC12A6 |
0.457 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260911 |
Ser96 |
IEDLSQNsITGEHSQ |
Homo sapiens |
|
| pmid |
sentence |
| 24043619 |
WNK3, which inhibits the activity of KCC3, promoted phosphorylation of Ser-96 as well as Thr-991 and Thr-1048. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260910 |
Thr1048 |
YQEKVHMtWTKDKYM |
Homo sapiens |
|
| pmid |
sentence |
| 24043619 |
WNK3, which inhibits the activity of KCC3, promoted phosphorylation of Ser-96 as well as Thr-991 and Thr-1048. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260912 |
Thr991 |
SAYTYERtLMMEQRS |
Homo sapiens |
|
| pmid |
sentence |
| 24043619 |
WNK3, which inhibits the activity of KCC3, promoted phosphorylation of Ser-96 as well as Thr-991 and Thr-1048. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264629 |
|
|
|
|
| pmid |
sentence |
| 21613606 |
We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activates NKCC1/2 and NCC and inhibits the KCCs |
|
| Publications: |
4 |
Organism: |
Homo Sapiens, |
| + |
WNK1 | down-regulates
phosphorylation
|
SLC12A6 |
0.466 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187560 |
Thr1048 |
YQEKVHMtWTKDKYM |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19665974 |
We have attempted to identify kinases and phosphatases involved in the modulation of phosphorylation at kcc3 t991 and t1048. the wnk kinases and spak/osr1 are strong candidates for kcc3 regulatory kinases. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187564 |
Thr991 |
SAYTYERtLMMEQRS |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 19665974 |
We have attempted to identify kinases and phosphatases involved in the modulation of phosphorylation at kcc3 t991 and t1048. the wnk kinases and spak/osr1 are strong candidates for kcc3 regulatory kinases. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
SLC12A6 | down-regulates quantity
relocalization
|
chloride |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264638 |
|
|
|
|
| pmid |
sentence |
| 21613606 |
Eukaryotic cells regulate their volume in the long term through the coordinated function of the Na+-coupled chloride (NKCC1/2 and NCC) and K+-coupled chloride (KCC1–4) cotransporters, which encompass two branches of the SLC12|The K+-Cl− cotransporters move chloride outside the cell, are inhibited by phosphorylation, and are activated by dephosphorylation. In contrast, the Na+-K+-2Cl− cotransporters introduce chloride into the cell, are inhibited by dephosphorylation, and are activated by phosphorylation gene family of solute transporters (12). |
|
| Publications: |
1 |
3.0
SLC12A6
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- 