3.0
Summary
| Name |  DAPK2View Modifications |
| Full Name | Death-associated protein kinase 2 |
| Synonyms | DAP kinase 2, DAP-kinase-related protein 1, DRP-1 |
| Primary ID | Q9UIK4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421). |
phosphorylation