3.0
Summary
| Name |  FBXL3
|
| Full Name | F-box/LRR-repeat protein 3 |
| Synonyms | F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3A | FBL3A, FBXL3A |
| Primary ID | Q9UKT7 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation (PubMed:17463251, PubMed:23452855, PubMed:27565346). The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 (PubMed:17463251, PubMed:23452855, PubMed:27565346). Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex (PubMed:23452855). {ECO:0000269|PubMed:17463251, ECO:0000269|PubMed:23452855, ECO:0000269|PubMed:27565346}. |
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