Summary

Name HCN2
Full Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Synonyms Brain cyclic nucleotide-gated channel 2, BCNG-2 | BCNG2
Primary ID Q9UL51
Links - -
Type protein
Relations 2
Function Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation HCN2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation HCN2 0.27
Publications: 1 Organism: Homo Sapiens