3.0
Summary
| Name |  MED23
|
| Full Name | Mediator of RNA polymerase II transcription subunit 23 |
| Synonyms | Activator-recruited cofactor 130 kDa component, ARC130, Cofactor required for Sp1 transcriptional activation subunit 3, CRSP complex subunit 3, Mediator complex subunit 23, Protein sur-2 homolog, hSur-2, Transcriptional coactivator CRSP130, Vitamin D3 receptor-interacting protein complex 130 kDa component, DRIP130 | ARC130, CRSP3, DRIP130, KIAA1216, SUR2 |
| Primary ID | Q9ULK4 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MED23 | form complex 
binding
|
Core mediator complex | 0.727 |
| Publications: | 1 | Organism: | Homo Sapiens | |