3.0
The
SIG
naling
N
etwork
O
pen
R
esource
HOME
ABOUT
DOCUMENTATION
USER GUIDE
STATISTICS
DOWNLOADS
APIs
CONTACT
LOGIN
Summary
Name
EDAR
Full Name
Tumor necrosis factor receptor superfamily member EDAR
Synonyms
Anhidrotic ectodysplasin receptor 1, Downless homolog, EDA-A1 receptor, Ectodermal dysplasia receptor, Ectodysplasin-A receptor | DL
Primary ID
Q9UNE0
Links
-
-
Type
protein
Relations
1
Function
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Viewer
Search Tools
Refine search:
by mechanism
none
binding
by effect
none
up-regulates
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
Relations
Regulator
Mechanism
target
score
ℹ
+
EDA
up-regulates
binding
EDAR
0.743
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-161109
Homo sapiens
pmid
sentence
18304980
Ultimately, in mammals, eda-a1 and eda-a2 trimers each bind a different receptor, edar and xedar, respectively, through their trimerized tnf domain.
Publications:
1
Organism:
Homo Sapiens